In 2010, Pescatelli won Comedy Central's Standup Showdown. In 2004, she was a finalist on the second and third seasons of Last Comic Standing. She was one of the Final Five on NBC‘s Last Comic Standing.

Pescatelli co-created, executive produced, wrote and starred in a reality television show on WE tv, called A Standup Mother (2011), related to Pescatelli's life as a mother, wife, and comedian.

Her comedy special, Finding the Funny, was released with Netflix in 2013. That same special was selected "New and Noteworthy" by iTunes editors and also hit number 3 on the charts.

She was chosen four years in a row to be included in The New York Post greatest jokes from the past year.